Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | DUT | P33316 | 4/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565836 | 0.99 | HDAC4 (0.41) | HDAC4MEF2DMTNR1AKAT6AEPHX2 | |
| SCHEMBL13565527 | 0.87 | CTSL (0.38) | MTNR1AEPHX2CNR2GRM2ALDH1A1 | |
| SCHEMBL11935682 | 0.85 | ACACB (0.38) | MTNR1ACNR2ALDH1A1LMNAMAPT | |
| SCHEMBL13565964 | 0.85 | HDAC4 (0.41) | HDAC4MEF2DMTNR1ADUTF2 | |
| SCHEMBL10115175 | 0.85 | MEN1 (0.46) | HDAC4MEF2DMTNR1AF2PLG | |
| SCHEMBL13565272 | 0.84 | GRIA1 (0.41) | HDAC4MEF2DMTNR1AKAT6ADUT | |
| SCHEMBL10115278 | 0.84 | ALDH1A1 (0.45) | HDAC4MEF2DF2PLGPLAU | |
| SCHEMBL13565791 | 0.82 | DUT (0.42) | MTNR1AKAT6ADUTCNR2 | |
| SCHEMBL13565878 | 0.81 | HRH3 (0.37) | MTNR1AEPHX2DUTCNR2ALDH1A1 | |
| SCHEMBL13565261 | 0.80 | CNR2 (0.40) | EPHX2CNR2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |