Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11936096 | 0.84 | PARP1 (0.42) | PARP1PPARAGRIA2RXRARXRB | |
| SCHEMBL13565080 | 0.83 | RXRA (0.40) | PARP1PPARAGRIA2HTTSMN1; SMN2 | |
| SCHEMBL13565505 | 0.83 | SMN1; SMN2 (0.56) | PARP1HTTSMN1; SMN2NPSR1RXRA | |
| SCHEMBL13565355 | 0.82 | METAP2 (0.35) | HTTSMN1; SMN2NPSR1RXRARXRB | |
| SCHEMBL10116637 | 0.78 | LMNA (0.41) | GRIA2HTTLMNATP53MAPT | |
| SCHEMBL11936098 | 0.76 | PARP1 (0.36) | PARP1PPARACA1CA2CA9 | |
| SCHEMBL13565070 | 0.76 | PPARA (0.50) | PPARASMN1; SMN2CA1CA2BRD4 | |
| SCHEMBL13565984 | 0.76 | CA1 (0.59) | HTTSMN1; SMN2CA1CA2CA9 | |
| SCHEMBL11936110 | 0.75 | PARP1 (0.37) | PARP1GRIA2HTTSMN1; SMN2NPSR1 | |
| SCHEMBL17090103 | 0.75 | ALDH1A1 (0.43) | PPARASMN1; SMN2HDAC6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |