Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11936208 | 1.00 | NR3C1 (0.46) | NR3C1GRIA2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL13565751 | 0.91 | NR3C1 (0.44) | NR3C1ALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL11936207 | 0.87 | ALDH1A1 (0.43) | NR3C1ALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL13565676 | 0.86 | MET (0.45) | GRIA2ALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL13565703 | 0.85 | NR3C1 (0.42) | NR3C1ALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL11936220 | 0.85 | NR3C1 (0.42) | NR3C1ALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL13565511 | 0.84 | GRIA2 (0.43) | GRIA2NPC1MEN1KMT2AMET | |
| SCHEMBL11936270 | 0.83 | GRIA2 (0.43) | GRIA2ALDH1A1LMNACYP2C19CYP1A2 | |
| SCHEMBL10114035 | 0.80 | EPHX2 (0.56) | GRIA2NPC1POLBMEN1MAPT | |
| SCHEMBL13493847 | 0.80 | NPC1 (0.49) | NR3C1ALDH1A1LMNASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |