Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 5/20 | 0.36 |
| ▸ | MMP13 | P45452 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11935090 | 0.90 | ACHE (0.41) | ACHEBACE1NPY5RPGRMAPT | |
| SCHEMBL13565599 | 0.85 | NPC1 (0.41) | MAPTALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL17089944 | 0.81 | ALDH1A1 (0.42) | ACHEBACE1NPY5RPGRMAPT | |
| SCHEMBL13565600 | 0.81 | ALDH1A1 (0.42) | ACHEBACE1NPY5RPGRMAPT | |
| SCHEMBL10114238 | 0.81 | SMN1; SMN2 (0.56) | NPY5RMAPTHTTSMN1; SMN2RECQL | |
| SCHEMBL13565429 | 0.80 | BRD4 (0.41) | NPY5RMAPTALDH1A1HTTLMNA | |
| SCHEMBL17090178 | 0.80 | CRHR1 (0.41) | NPY5RCNR2EPHX2 | |
| SCHEMBL13565534 | 0.80 | MAPT (0.41) | MAPTALDH1A1SMN1; SMN2LMNACNR1 | |
| SCHEMBL13566025 | 0.80 | CRHR1 (0.41) | NPY5RCNR2EPHX2 | |
| SCHEMBL13565523 | 0.79 | LMNA (0.38) | MAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |