Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1201754 | 0.88 | ALDH1A1 (0.42) | ALDH1A1MAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL13572300 | 0.84 | HPGDS (0.39) | MEN1KMT2AHPGDSNPC1RAB9A | |
| SCHEMBL1201804 | 0.80 | HDAC1 (0.39) | KDM4ENPC1RAB9A | |
| SCHEMBL4247706 | 0.80 | ALDH1A1 (0.43) | ALDH1A1MAPK1HSD17B10KMT2AROCK2 | |
| SCHEMBL4247703 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MAPK1HSD17B10ROCK2NAMPT | |
| SCHEMBL13572248 | 0.78 | PTGES (0.37) | MAPK1HPGDSKDM4ERAB9A | |
| SCHEMBL13572193 | 0.77 | RAB9A (0.39) | ALDH1A1MEN1KMT2ABRAFHPGDS | |
| SCHEMBL1201025 | 0.75 | HPGDS (0.40) | MEN1KMT2AHPGDSNPC1RAB9A | |
| SCHEMBL13572154 | 0.74 | PTGES (0.39) | MEN1KMT2AHPGDSNPC1RAB9A | |
| SCHEMBL13571916 | 0.74 | NPC1 (0.51) | MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863771-B1 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2012-11-07 | — | — | EP | claimed |