Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.31 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1613330 | 0.88 | ERN1 (0.36) | ALDH1A1GAAP2RX3P2RX2KDM4E | |
| SCHEMBL13575032 | 0.82 | JAK2 (0.34) | ALDH1A1P2RX3P2RX2TSHRJAK2 | |
| SCHEMBL13575104 | 0.75 | TTBK1 (0.39) | P2RX3P2RX2 | |
| SCHEMBL1612242 | 0.69 | MAPT (0.36) | JAK2JAK1TYK2KDRJAK3 | |
| SCHEMBL1613738 | 0.62 | TTBK1 (0.39) | P2RX3P2RX2 | |
| SCHEMBL13736042 | 0.60 | NUDT1 (0.39) | ALDH1A1P2RX3P2RX2KDM4ETSHR | |
| SCHEMBL24488264 | 0.58 | P2RX3 (0.36) | ALDH1A1P2RX3P2RX2KDM4ETSHR | |
| SCHEMBL24686301 | 0.58 | ERN1 (0.43) | ALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL27932794 | 0.56 | DHFR (0.44) | ALDH1A1GAAP2RX3P2RX2KDM4E | |
| SCHEMBL20346248 | 0.56 | ERN1 (0.39) | ALDH1A1KDM4ETSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |