Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.48 |
| ▸ | SKP1 | P63208 | 2/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.48 |
| ▸ | GBA1 | P04062 | 2/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10095059 | 0.87 | CKS1B (0.47) | CKS1BSKP1SKP2GBA1NR1H2 | |
| SCHEMBL10095061 | 0.87 | CKS1B (0.47) | CKS1BSKP1SKP2GBA1NR1H2 | |
| SCHEMBL10095062 | 0.85 | P2RX7 (0.59) | CKS1BSKP1SKP2GBA1NR1H2 | |
| SCHEMBL20139779 | 0.80 | TSHR (0.62) | NR1H2MAPK1TSHR | |
| SCHEMBL20157515 | 0.80 | PDK2 (0.64) | CKS1BSKP1SKP2GBA1NR1H2 | |
| SCHEMBL1173978 | 0.78 | CKS1B (0.49) | CKS1BSKP1SKP2GBA1NR1H2 | |
| SCHEMBL20140942 | 0.75 | CKS1B (0.49) | CKS1BSKP1SKP2GBA1MAPK1 | |
| SCHEMBL13867707 | 0.74 | CKS1B (0.48) | CKS1BSKP1SKP2GBA1NR1H2 | |
| SCHEMBL1232845 | 0.74 | GBA1 (0.46) | CKS1BSKP1SKP2GBA1NR1H2 | |
| SCHEMBL10095056 | 0.74 | GPR119 (0.43) | CKS1BSKP1SKP2NR1H2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158394-A1 | DIKETO AZOLOPIPERIDINES AND AZOLOPIPERAZINES AS ANTI-HIV AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-30 | — | — | WO | disclosed |