Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 7/20 | 0.45 |
| ▸ | GABRD | O14764 | 7/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.45 |
| ▸ | GABRE | P78334 | 7/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 7/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 7/20 | 0.45 |
| ▸ | GABRQ | Q9UN88 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5457757 | 0.80 | PTPN1 (0.54) | PTPN1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10274545 | 0.80 | PTPN1 (0.64) | PTPN1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9095871 | 0.79 | ALDH1A1 (0.46) | PTPN1TDP1GABRPGABRDGABRA1 | |
| SCHEMBL2086919 | 0.78 | GABRP (0.66) | PTPN1TDP1GABRPGABRDGABRA1 | |
| SCHEMBL135906 | 0.77 | TDP1 (0.50) | PTPN1TDP1ALDH1A1MAPTLMNA | |
| SCHEMBL136844 | 0.76 | TDP1 (0.74) | TDP1ALDH1A1MAPTLMNAGAA | |
| SCHEMBL133029 | 0.76 | TDP1 (0.70) | TDP1ALDH1A1MAPTLMNAGAA | |
| SCHEMBL30988084 | 0.75 | GABRP (0.48) | PTPN1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30988100 | 0.75 | HSD17B10 (0.60) | PTPN1TDP1GABRPGABRDGABRA1 | |
| SCHEMBL135846 | 0.75 | TDP1 (0.72) | TDP1ALDH1A1MAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430029-B1 | THIENO[2,3-B]PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | UNIV LEUVEN KATH (BE) | 2018-01-10 | — | — | EP | disclosed |
| US-9499563-B2 | Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2016-11-22 | — | — | US | disclosed |
| US-20140296272-A1 | THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | CISTIM LEUVEN VZW (BE) | 2014-10-02 | — | — | US | disclosed |
| US-8785638-B2 | Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2014-07-22 | — | — | US | disclosed |
| EP-2430029-A1 | THIENO [2, 3-B]PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | Katholieke Universiteit Leuven (BE) | 2012-03-21 | — | — | EP | disclosed |
| US-20120059028-A1 | THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2012-03-08 | — | — | US | disclosed |
| WO-2010130842-A1 | THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2010-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296272-A1 | THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | TYMP, DUT, MAVS | PTPN1 2792/4885TDP1 928/4885GABRP 2973/4885 |
| US-20120059028-A1 | THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | TYMP, DUT, MAVS | PTPN1 2792/4885TDP1 928/4885GABRP 2973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.