SCHEMBL1358148

SCHEMBL1358148

C=CC(=O)NC1CCCC1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 6/20 0.55
NPC1 O15118 5/20 0.55
HTT P42858 1/20 0.55
GAA P10253 1/20 0.55
EPHX1 P07099 5/20 0.52
RAB9A P51151 3/20 0.52
MAPT P10636 1/20 0.52
KDM4E B2RXH2 1/20 0.52
ALDH1A1 P00352 1/20 0.52
CYP3A4 P08684 1/20 0.52
EPHX2 P34913 1/20 0.52
TEAD1 P28347 2/20 0.45
MMP2 P08253 4/20 0.45
CA12 O43570 3/20 0.45
CA1 P00915 3/20 0.45
CA2 P00918 3/20 0.45
CA9 Q16790 3/20 0.45
MMP1 P03956 2/20 0.45
POLB P06746 1/20 0.45
SMYD3 Q9H7B4 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL81398 0.98 NPC1 (0.59) SMN1; SMN2NPC1HTTGAAEPHX1
SCHEMBL6435991 0.98 NPC1 (0.59) SMN1; SMN2NPC1HTTGAAEPHX1
SCHEMBL6436241 0.98 NPC1 (0.59) SMN1; SMN2NPC1HTTGAAEPHX1
SCHEMBL6431667 0.98 NPC1 (0.59) SMN1; SMN2NPC1HTTGAAEPHX1
SCHEMBL127819 0.95
Vinyl Chloride SCHEMBL11146132 0.92 NPC1 (0.53) SMN1; SMN2NPC1HTTGAAEPHX1
SCHEMBL308515 0.90
SCHEMBL9624068 0.90 POLB (0.54) SMN1; SMN2NPC1HTTGAAEPHX1
SCHEMBL22784002 0.90 NPC1 (0.52) SMN1; SMN2NPC1HTTGAAEPHX1
Acrylamide SCHEMBL27873607 0.90 NPC1 (0.52) SMN1; SMN2NPC1HTTGAAEPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190023972-A1 SHALE SWELLING INHIBITORS ISP INVESTMENTS LLC (US) 2019-01-24 US claimed
EP-2414456-B1 DEGRADABLE POLYMER COMPOSITIONS AND USES THEREOF ISP INVESTMENTS LLC (US) 2018-12-26 EP claimed
US-10081757-B2 Shale swelling inhibitors ISP INVESTMENTS LLC (US) 2018-09-25 US claimed
EP-2346909-B1 POLYMERS DERIVED FROM N-VINYL FORMAMIDE, VINYL AMIDES OR ACRYLAMIDES, AND REACTION SOLVENT, AND THE USES THEREOF ISP INVESTMENTS INC (US) 2018-05-16 EP claimed
US-20150344767-A1 SHALE SWELLING INHIBITORS ISP INVESTMENTS INC. (US) 2015-12-03 US claimed
US-8895478-B2 Degradable polymer compositions and uses thereof ISP INVESTMENTS INC. (US) 2014-11-25 US claimed
WO-2014088850-A2 SHALE SWELLING INHIBITORS ISP INVESTMENTS INC. (US) 2014-06-12 WO claimed
US-20120157352-A1 DEGRADABLE POLYMER COMPOSITIONS AND USES THEREOF ISP INVESTMENTS INC. (US) 2012-06-21 US claimed
US-20110277844-A1 POLYMERS DERIVED FROM N-VINYL FORMAMIDE, VINYL AMIDES OR ACRYLAMIDES, AND REACTION SOLVENT, AND THE USES THEREOF HERCULES LLC 2011-11-17 US claimed
EP-0774096-B1 A METHOD FOR INHIBITING HYDRATE FORMATION EXXON PRODUCTION RESEARCH CO (US) 2000-03-01 EP claimed
EP-0774096-A4 A METHOD FOR INHIBITING HYDRATE FORMATION EXXON PRODUCTION RESEARCH CO (US) 1999-01-13 EP claimed
EP-0774096-A1 A METHOD FOR INHIBITING HYDRATE FORMATION EXXON PRODUCTION RESEARCH COMPANY (US) 1997-05-21 EP claimed
US-5600044-A USING A WATER SOLUBLE N-ALKYLACRYLAMIDE POLYMER EXXON PRODUCTION RESEARCH COMPANY (US) 1997-02-04 US claimed
WO-1996008672-A1 A METHOD FOR INHIBITING HYDRATE FORMATION EXXON PRODUCTION RESEARCH COMPANY (US) 1996-03-21 WO claimed
US-20230286904-A1 INHIBITORS OF YAP/TAZ-TEAD ONCOPROTEINS, SYNTHESIS AND USE THEREOF BRIDGENE BIOSCIENCES, INC. 2023-09-14 US disclosed
WO-2023156599-A1 SYNTHESIS OF BRUTON'S TYROSINE KINASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2023-08-24 WO disclosed
US-20230121556-A1 COMPOUNDS FOR FAST AND EFFICIENT CLICK RELEASE TAGWORKS PHARMACEUTICALS B.V. (NL) 2023-04-20 US disclosed
US-4945006-A UNSATURATED CYCLIC AMIDES, ANAEROBIC PROCESS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1990-07-31 US disclosed
EP-0379305-A1 Low odor adhesive compositions MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1990-07-25 EP disclosed
US-3936473-A COPPER OR NOBLE METAL SALT, OXYGEN AND ORGANIC ACID CATALYST UNIVERSAL OIL PRODUCTS COMPANY (US) 1976-02-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230286904-A1 INHIBITORS OF YAP/TAZ-TEAD ONCOPROTEINS, SYNTHESIS AND USE THEREOF TEAD1, TEAD2, TEAD3 SMN1; SMN2 1765/4885NPC1 4257/4885HTT 2488/4885
US-20230121556-A1 COMPOUNDS FOR FAST AND EFFICIENT CLICK RELEASE LTB4R, LTC4S, LTA4H SMN1; SMN2 3664/4885NPC1 670/4885HTT 2964/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.