Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2477156 | 1.00 | LMNA (0.42) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL28493300 | 0.83 | LMNA (0.47) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL2474757 | 0.83 | LMNA (0.47) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL5525837 | 0.82 | LMNA (0.50) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL16561617 | 0.80 | GABRA1 (0.41) | ALDH1A1TDP1L3MBTL1MAPK1HSP90AA1 | |
| SCHEMBL27777980 | 0.80 | LMNA (0.39) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL16950494 | 0.78 | LMNA (0.38) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL25189427 | 0.78 | LMNA (0.34) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL29280989 | 0.78 | LMNA (0.38) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL25194055 | 0.78 | LMNA (0.34) | LMNATRPA1CHRM1SLC6A2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10584119-B2 | Pyrazole compounds and methods of use thereof | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2020-03-10 | — | — | US | disclosed |
| US-20190084974-A1 | PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2019-03-21 | — | — | US | disclosed |
| US-10131654-B2 | Pyrazole compounds and methods of use thereof | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2018-11-20 | — | — | US | disclosed |
| US-20160009702-A1 | PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2016-01-14 | — | — | US | disclosed |
| US-9012443-B2 | Bicyclic aryl and heteroaryl sodium channel inhibitors | AMGEN INC. (US) | 2015-04-21 | — | — | US | disclosed |
| WO-2014138616-A2 | PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2014-09-12 | — | — | WO | disclosed |
| US-20130158036-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | PANMIRA PHARMACEUTICALS, LLC (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130150339-A1 | Bicyclic Aryl and Heteroaryl Sodium Channel Inhibitors | AMGEN INC. (US) | 2013-06-13 | — | — | US | disclosed |
| US-8362044-B2 | N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors | PANMIRA PHARMACEUTICALS, LLC (US) | 2013-01-29 | — | — | US | disclosed |
| WO-2012067663-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-05-24 | — | — | WO | disclosed |
| US-20120058123-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | PANMIRA PHARMACEUTICALS, LLC. (US) | 2012-03-08 | — | — | US | disclosed |
| US-20110039852-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158036-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | PTGDR, PTGDR2, PTGER2 | LMNA 1875/4885TRPA1 201/4885CHRM1 1532/4885 |
| US-20160009702-A1 | PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF | MKI67, CCNI, PDK1 | LMNA 2148/4885TRPA1 4579/4885CHRM1 4607/4885 |
| US-20110039852-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | PTGDR, PTGDR2, PTGER2 | LMNA 1875/4885TRPA1 201/4885CHRM1 1532/4885 |
| US-20120058123-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | PTGDR, PTGDR2, PTGER2 | LMNA 1875/4885TRPA1 201/4885CHRM1 1532/4885 |
| US-20130150339-A1 | Bicyclic Aryl and Heteroaryl Sodium Channel Inhibitors | SCN1A, SCN1B, CACNA1B | LMNA 1896/4885TRPA1 61/4885CHRM1 2449/4885 |
| US-10584119-B2 | Pyrazole compounds and methods of use thereof | MKI67, CCNI, PDK1 | LMNA 2148/4885TRPA1 4579/4885CHRM1 4607/4885 |
| US-10131654-B2 | Pyrazole compounds and methods of use thereof | MKI67, CCNI, PDK1 | LMNA 2148/4885TRPA1 4579/4885CHRM1 4607/4885 |
| US-20190084974-A1 | PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF | MKI67, CCNI, PDK1 | LMNA 2148/4885TRPA1 4579/4885CHRM1 4607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.