Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.42 |
| ▸ | F10 | P00742 | 3/20 | 0.42 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29741499 | 0.95 | SMN1; SMN2 (0.65) | NPC1HTTSMN1; SMN2HRH3HRH1 | |
| SCHEMBL255160 | 0.80 | AKR1C3 (0.51) | NPC1SMN1; SMN2HRH3AKR1C3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5650408 | 0.79 | L3MBTL1 (0.48) | NPC1HTTSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL15491817 | 0.79 | AKR1C3 (0.50) | NPC1SMN1; SMN2HRH3AKR1C3ALDH1A1 | |
| SCHEMBL8356124 | 0.79 | AKR1C3 (0.50) | NPC1SMN1; SMN2HRH3AKR1C3ALDH1A1 | |
| SCHEMBL2343208 | 0.78 | AKR1C3 (0.49) | HRH3HRH1AKR1C3ALDH1A1BRD9 | |
| SCHEMBL3593687 | 0.78 | NTRK1 (0.52) | NPC1HTTSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL3593684 | 0.77 | NPC1 (0.44) | NPC1HTTSMN1; SMN2HRH3CHRNB2 | |
| SCHEMBL3594508 | 0.77 | CHRNB2 (0.56) | NPC1HTTSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL12279805 | 0.77 | AKR1C3 (0.50) | NPC1SMN1; SMN2HRH3HRH1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067457-B2 | Compounds useful as antagonists of CCR2 | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090197884-A1 | Compounds Useful as Antagonists of CCR2 | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197884-A1 | Compounds Useful as Antagonists of CCR2 | CCR2, CCR1, CXCR3 | NPC1 712/4885HTT 3072/4885SMN1; SMN2 3742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.