Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19286213 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2CHRNA7ACHETDP1TAS1R3 | |
| SCHEMBL12654171 | 0.79 | HSD17B10 (0.46) | SMN1; SMN2MEN1KMT2ANPSR1HTR1A | |
| SCHEMBL2662574 | 0.75 | TYR (0.55) | SMN1; SMN2KDM4EALDH1A1GAAGRIA4 | |
| SCHEMBL178538 | 0.73 | ALDH1A1 (0.52) | SMN1; SMN2CHRNA7ACHETDP1TAS1R3 | |
| SCHEMBL8284259 | 0.73 | ALDH1A1 (0.52) | SMN1; SMN2CHRNA7ACHETDP1TAS1R3 | |
| SCHEMBL8285887 | 0.73 | ALDH1A1 (0.52) | SMN1; SMN2CHRNA7ACHETDP1TAS1R3 | |
| SCHEMBL2663534 | 0.71 | LMNA (0.41) | SMN1; SMN2CHRNA7ACHETDP1TAS1R3 | |
| SCHEMBL14305054 | 0.71 | SMN1; SMN2 (0.41) | SMN1; SMN2CHRNA7ACHETDP1TAS1R3 | |
| SCHEMBL6114224 | 0.71 | SMN1; SMN2 (0.41) | SMN1; SMN2CHRNA7ACHETDP1TAS1R3 | |
| SCHEMBL11947945 | 0.71 | LMNA (0.41) | SMN1; SMN2CHRNA7ACHETDP1TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625938-B2 | Substituted pyrazoles, compositions containing such compounds and methods of use | MERCK & CO., INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-20080108620-A1 | Substituted Pyrazoles, Compositions Containing such Compounds and Methods of Use | MERCK & CO., INC. (US) | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108620-A1 | Substituted Pyrazoles, Compositions Containing such Compounds and Methods of Use | GLP1R, GCGR, GPR119 | SMN1; SMN2 4364/4885CHRNA7 2740/4885ACHE 3929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.