Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13593118 | 0.90 | CNR1 (0.46) | CNR1MAPTLMNAABCB1SMN1; SMN2 | |
| SCHEMBL3552729 | 0.90 | CNR1 (0.44) | CNR1MAPTLMNATHRBCNR2 | |
| SCHEMBL13593120 | 0.89 | LMNA (0.52) | CNR1MAPTLMNACNR2GAA | |
| SCHEMBL13593112 | 0.82 | MEN1 (0.45) | CNR1CNR2 | |
| SCHEMBL13593119 | 0.81 | TSPO (0.43) | CNR1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL13593117 | 0.79 | CNR1 (0.41) | CNR1CNR2 | |
| SCHEMBL13593113 | 0.79 | CNR1 (0.52) | CNR1CNR2 | |
| SCHEMBL3555218 | 0.78 | TP53 (0.45) | CNR1MAPTLMNASMN1; SMN2CNR2 | |
| SCHEMBL3562031 | 0.77 | PDK1 (0.42) | CNR1CNR2 | |
| SCHEMBL3556587 | 0.77 | MGLL (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632837-B2 | Bicyclic heterocycles as cannabinoid-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-15 | — | — | US | disclosed |
| US-7632837-B2 | Bicyclic heterocycles as cannabinoid-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-15 | — | — | US | disclosed |