Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.48 |
| ▸ | KCNQ4 | P56696 | 2/20 | 0.48 |
| ▸ | KCNQ5 | Q9NR82 | 2/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25855122 | 0.78 | HTR2B (0.51) | MAOBLMNA | |
| SCHEMBL5073940 | 0.76 | TGM2 (0.54) | — | |
| SCHEMBL13594564 | 0.75 | HASPIN (0.42) | — | |
| SCHEMBL26101571 | 0.75 | EGFR (0.61) | MAOBEPHX2HDAC8HDAC6HDAC3 | |
| SCHEMBL30241337 | 0.73 | FGFR1 (0.58) | MAOBEPHX2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL26099975 | 0.73 | FGFR1 (0.58) | MAOBEPHX2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL17154057 | 0.73 | KCNQ3 (0.58) | MAOBEPHX2HDAC8HDAC6HDAC3 | |
| SCHEMBL23902638 | 0.72 | EGFR (0.51) | MAOBEPHX2HDAC8HDAC6HDAC3 | |
| SCHEMBL30364613 | 0.72 | EGFR (0.51) | MAOBEPHX2HDAC8HDAC6HDAC3 | |
| SCHEMBL23902673 | 0.72 | KCNQ3 (0.52) | MAOBEPHX2HDAC8HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629319-B2 | Heteroaryl peptidomimetics as thrombin receptor antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-08 | — | — | US | disclosed |
| US-7618945-B2 | Heteroaryl peptidomimetics as thrombin receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-11-17 | — | — | US | disclosed |
| US-7618945-B2 | Heteroaryl peptidomimetics as thrombin receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-11-17 | — | — | US | disclosed |