Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 3/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4402395 | 0.77 | HASPIN (0.47) | HASPINENPP2POLBPLA2G2A | |
| SCHEMBL13594562 | 0.75 | MAOB (0.59) | — | |
| SCHEMBL4402392 | 0.70 | ICMT (0.45) | HASPINMAPTPOLBPLA2G2A | |
| SCHEMBL5073940 | 0.69 | TGM2 (0.54) | MAPT | |
| SCHEMBL3850606 | 0.67 | TUBB4A (0.55) | MAPTPOLB | |
| SCHEMBL14349999 | 0.65 | TUBB4A (0.49) | MAPTPOLB | |
| SCHEMBL25855377 | 0.64 | RAB9A (0.50) | MAPTPOLB | |
| SCHEMBL8804492 | 0.63 | YES1 (0.54) | MAPTPOLB | |
| SCHEMBL3360235 | 0.63 | SCD (0.73) | — | |
| SCHEMBL6699595 | 0.63 | THRB (0.47) | ENPP2MAPTPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629319-B2 | Heteroaryl peptidomimetics as thrombin receptor antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-08 | — | — | US | disclosed |
| US-7618945-B2 | Heteroaryl peptidomimetics as thrombin receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-11-17 | — | — | US | disclosed |
| US-7618945-B2 | Heteroaryl peptidomimetics as thrombin receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-11-17 | — | — | US | disclosed |