Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 4/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.32 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1359385 | 0.93 | MAPT (0.36) | CYP3A4MEN1ALDH1A1LMNAMAPT | |
| SCHEMBL1359911 | 0.93 | MAPT (0.34) | PARP1CYP3A4CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL1359529 | 0.92 | MAPT (0.37) | CYP3A4MEN1ALDH1A1LMNAMAPT | |
| SCHEMBL1358783 | 0.91 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL1357846 | 0.90 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL1360394 | 0.89 | PARP1 (0.41) | PARP1HPGDKMT2A | |
| SCHEMBL1358003 | 0.89 | CRBN (0.36) | CYP3A4CYP1A2CYP2C19CYP2C9CRBN | |
| SCHEMBL1360205 | 0.88 | KDM1A (0.38) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1360132 | 0.87 | CYP3A4 (0.35) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1358320 | 0.87 | ALDH1A1 (0.39) | PARP1CYP3A4ALDH1A1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067442-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2011-11-29 | — | — | US | claimed |
| US-20100081658-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | ROCHE PALO ALTO LLC | 2010-04-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081658-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | EIF2AK2, POLR2A, HCCS | HSP90AA1 2114/4885HSP90AB1 1378/4885PARP1 482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.