Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SLC6A7 | Q99884 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6655484 | 0.82 | SLC6A7 (0.62) | HPGDALDH1A1SLC6A7KDM4EPARP1 | |
| SCHEMBL4315496 | 0.82 | ALDH1A1 (0.48) | HPGDALDH1A1SLC6A7KDM4EHTT | |
| SCHEMBL13601358 | 0.81 | ALDH1A1 (0.64) | HPGDALDH1A1SLC6A7KDM4EABL1 | |
| SCHEMBL6653885 | 0.80 | ALDH1A1 (0.79) | HPGDALDH1A1SLC6A7KDM4EABL1 | |
| SCHEMBL6653746 | 0.79 | ALDH1A1 (0.60) | HPGDALDH1A1SLC6A7KDM4EABL1 | |
| SCHEMBL6655163 | 0.79 | ALDH1A1 (0.60) | HPGDALDH1A1SLC6A7KDM4EPARP1 | |
| Hydrochloric Acid SCHEMBL6651521 | 0.79 | ALDH1A1 (0.77) | HPGDALDH1A1SLC6A7KDM4EABL1 | |
| SCHEMBL6674771 | 0.78 | L3MBTL1 (0.59) | HPGDALDH1A1SLC6A7KDM4EHCRTR1 | |
| Hypochlorous Acid SCHEMBL6651528 | 0.78 | ALDH1A1 (0.76) | HPGDALDH1A1SLC6A7KDM4EABL1 | |
| Hydrochloric Acid SCHEMBL6651531 | 0.78 | ALDH1A1 (0.59) | HPGDALDH1A1KDM4EABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | GRM5, GRIK5, GRM1 | HPGD 2657/4885ALDH1A1 3104/4885SLC6A7 234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.