Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | DGKA | P23743 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8259120 | 0.94 | HPGD (0.49) | NAAANPSR1MAPTMAPK1L3MBTL1 | |
| SCHEMBL13601367 | 0.87 | ALDH1A1 (0.41) | MAPTHPGD | |
| SCHEMBL11855822 | 0.87 | NAAA (0.60) | NAAANPSR1MAPTMAPK1L3MBTL1 | |
| SCHEMBL13601407 | 0.85 | NAAA (0.47) | NAAAHRH3DGKAHTR2C | |
| SCHEMBL14611251 | 0.85 | GNAI3 (0.49) | NAAANPSR1MAPTMAPK1L3MBTL1 | |
| SCHEMBL12881348 | 0.84 | GNAI3 (0.55) | NAAANPSR1MAPTMAPK1L3MBTL1 | |
| SCHEMBL12772763 | 0.84 | GNAI3 (0.55) | NAAANPSR1MAPTMAPK1L3MBTL1 | |
| SCHEMBL12120098 | 0.83 | NPSR1 (0.55) | NAAANPSR1MAPTMAPK1L3MBTL1 | |
| SCHEMBL12120093 | 0.83 | NPSR1 (0.55) | NAAANPSR1MAPTMAPK1L3MBTL1 | |
| SCHEMBL12120088 | 0.83 | NPSR1 (0.55) | NAAANPSR1MAPTMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |