Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601418 | 0.92 | POLB (0.46) | POLBHTTDNM1SMN1; SMN2KMT2A | |
| SCHEMBL12881392 | 0.86 | DNM1 (0.43) | POLBHTTDNM1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13601372 | 0.85 | CHRM2 (0.41) | POLBHTTDNM1SMN1; SMN2KMT2A | |
| SCHEMBL13601455 | 0.83 | POLB (0.51) | POLBHTTSMN1; SMN2KMT2AHRH3 | |
| SCHEMBL13601498 | 0.83 | DNM1 (0.49) | DNM1SMN1; SMN2KMT2AALDH1A1THRB | |
| SCHEMBL12774130 | 0.82 | TP53 (0.42) | DNM1SMN1; SMN2HRH3ALDH1A1THRB | |
| SCHEMBL13601630 | 0.82 | NPC1 (0.54) | POLBDNM1SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL13601405 | 0.81 | POLB (0.49) | POLBHTTKMT2AHRH3KDM4E | |
| SCHEMBL11668905 | 0.81 | ALDH1A1 (0.48) | POLBDNM1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL12881452 | 0.80 | TP53 (0.42) | DNM1SMN1; SMN2HRH3ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |