Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601437 | 0.85 | POLB (0.48) | MAPTSMN1; SMN2ALDH1A1HTTMEN1 | |
| SCHEMBL12773981 | 0.84 | GNAI3 (0.36) | MAPTSMN1; SMN2ALDH1A1RAB9AMEN1 | |
| SCHEMBL2663390 | 0.82 | MAPT (0.48) | MAPTSMN1; SMN2ALDH1A1HTTRAB9A | |
| SCHEMBL5236867 | 0.81 | ALDH1A1 (0.50) | MAPTSMN1; SMN2ALDH1A1HTTRAB9A | |
| SCHEMBL13601613 | 0.81 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL12774077 | 0.80 | ACHE (0.37) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL13601372 | 0.78 | CHRM2 (0.41) | MAPTSMN1; SMN2ALDH1A1HTTRAB9A | |
| SCHEMBL12774035 | 0.77 | L3MBTL3 (0.36) | MAPTALDH1A1KDM4ETP53 | |
| SCHEMBL13601375 | 0.76 | NPC1 (0.39) | SMN1; SMN2ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL13601367 | 0.76 | ALDH1A1 (0.41) | MAPTSMN1; SMN2ALDH1A1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |