Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 8/20 | 0.60 |
| ▸ | THRA | P10827 | 5/20 | 0.60 |
| ▸ | NAAA | Q02083 | 1/20 | 0.51 |
| ▸ | DGKA | P23743 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499698 | 1.00 | THRB (0.60) | THRBTHRANAAADGKAHTR2C | |
| SCHEMBL4979398 | 0.95 | NAAA (0.56) | THRBTHRANAAADGKAHTR2C | |
| SCHEMBL11711713 | 0.95 | NAAA (0.56) | THRBTHRANAAADGKAHTR2C | |
| SCHEMBL13601497 | 0.94 | THRB (0.56) | THRBTHRANAAADGKANPC1 | |
| SCHEMBL18068757 | 0.92 | THRB (0.51) | THRBTHRANAAADGKAHTR2C | |
| SCHEMBL15848363 | 0.91 | THRB (0.55) | THRBTHRANAAADGKAHTR2C | |
| SCHEMBL15848329 | 0.91 | THRB (0.55) | THRBTHRANAAADGKAHTR2C | |
| SCHEMBL15848517 | 0.91 | THRB (0.55) | THRBTHRANAAADGKAHTR2C | |
| SCHEMBL673095 | 0.89 | DGKA (0.50) | THRBTHRANAAADGKAHTR2C | |
| SCHEMBL11598618 | 0.89 | DGKA (0.50) | THRBTHRANAAADGKAHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |