Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601667 | 0.91 | TSHR (0.42) | DNM1TSHRLMNAPOLBALDH1A1 | |
| SCHEMBL12881502 | 0.89 | GNAI3 (0.50) | DNM1TSHRLMNAPOLBALDH1A1 | |
| SCHEMBL12881513 | 0.88 | BDKRB1 (0.43) | DNM1TSHRLMNAPOLBALDH1A1 | |
| SCHEMBL12881518 | 0.87 | BDKRB1 (0.43) | DNM1TSHRLMNAPOLBALDH1A1 | |
| SCHEMBL13601630 | 0.84 | NPC1 (0.54) | DNM1TSHRLMNAPOLBALDH1A1 | |
| SCHEMBL13601654 | 0.83 | TSHR (0.51) | TSHRLMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL13601498 | 0.81 | DNM1 (0.49) | DNM1ALDH1A1SMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL12881501 | 0.81 | GNAI3 (0.51) | DNM1TSHRLMNAPOLBALDH1A1 | |
| SCHEMBL12881521 | 0.81 | BDKRB1 (0.42) | DNM1TSHRLMNAPOLBALDH1A1 | |
| SCHEMBL16015485 | 0.80 | HTR1A (0.46) | LMNAALDH1A1SMN1; SMN2HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |