Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601676 | 0.86 | MAPT (0.53) | MAPTGAAL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL12496523 | 0.84 | MAPT (0.67) | MAPTGAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL23167854 | 0.84 | GAA (0.69) | MAPTGAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL13601680 | 0.83 | HPGD (0.56) | MAPTGAAL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL1267094 | 0.82 | GAA (0.65) | MAPTGAAL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL12418600 | 0.82 | MAPT (0.49) | MAPTGAAL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL13601702 | 0.82 | MAPT (0.49) | MAPTGAAL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL12881458 | 0.81 | MAPT (0.64) | MAPTGAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL13601682 | 0.80 | HPGD (0.50) | MAPTGAAL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL6331933 | 0.80 | MAPT (0.62) | MAPTGAAL3MBTL1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |