Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601682 | 0.94 | HPGD (0.50) | HPGDMAPTGAANPC1ALDH1A1 | |
| SCHEMBL13601676 | 0.90 | MAPT (0.53) | HPGDMAPTGAANPC1ALDH1A1 | |
| SCHEMBL13601690 | 0.84 | MAPT (0.44) | HPGDMAPTGAANPC1ALDH1A1 | |
| SCHEMBL7339506 | 0.83 | LMNA (0.61) | HPGDMAPTGAANPC1ALDH1A1 | |
| SCHEMBL13601675 | 0.83 | MAPT (0.70) | HPGDMAPTGAANPC1ALDH1A1 | |
| SCHEMBL28060009 | 0.81 | ALDH1A1 (0.53) | HPGDMAPTNPC1ALDH1A1MEN1 | |
| SCHEMBL13601693 | 0.81 | MAPT (0.46) | HPGDMAPTGAANPC1ALDH1A1 | |
| SCHEMBL13601726 | 0.80 | SMN1; SMN2 (0.45) | HPGDMAPTGAANPC1ALDH1A1 | |
| SCHEMBL5875276 | 0.79 | SMN1; SMN2 (0.44) | HPGDMAPTGAAALDH1A1MEN1 | |
| SCHEMBL12881455 | 0.78 | GNAI3 (0.58) | MAPTGAASMN1; SMN2L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |