Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NAAA | Q02083 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601680 | 0.94 | HPGD (0.56) | HPGDMAPTTSHRGAANPC1 | |
| SCHEMBL13601676 | 0.87 | MAPT (0.53) | HPGDMAPTTSHRGAANPC1 | |
| SCHEMBL12881455 | 0.84 | GNAI3 (0.58) | MAPTTSHRGAANAAANPSR1 | |
| SCHEMBL13601690 | 0.82 | MAPT (0.44) | HPGDMAPTGAANPC1ALDH1A1 | |
| SCHEMBL13601725 | 0.81 | TSHR (0.49) | HPGDMAPTTSHRGAANPC1 | |
| SCHEMBL12881468 | 0.81 | GNAI3 (0.42) | MAPTTSHRGAANAAAL3MBTL1 | |
| SCHEMBL13601675 | 0.80 | MAPT (0.70) | HPGDMAPTGAANPC1ALDH1A1 | |
| SCHEMBL13601628 | 0.78 | NPC1 (0.55) | HPGDTSHRNPC1NAAAALDH1A1 | |
| SCHEMBL13601693 | 0.78 | MAPT (0.46) | HPGDMAPTGAANPC1NPSR1 | |
| SCHEMBL12881482 | 0.78 | GNAI3 (0.42) | MAPTTSHRGAANAAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |