Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | LIPE | Q05469 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601680 | 0.90 | HPGD (0.56) | MAPTGAAHPGDALDH1A1NPC1 | |
| SCHEMBL13601682 | 0.87 | HPGD (0.50) | MAPTGAAHPGDALDH1A1NPC1 | |
| SCHEMBL13601675 | 0.86 | MAPT (0.70) | MAPTGAAHPGDALDH1A1NPC1 | |
| SCHEMBL13601693 | 0.83 | MAPT (0.46) | MAPTGAAHPGDALDH1A1NPC1 | |
| SCHEMBL14293823 | 0.82 | GAA (0.50) | GAAHPGDALDH1A1NPC1L3MBTL1 | |
| SCHEMBL13601690 | 0.81 | MAPT (0.44) | MAPTGAAHPGDALDH1A1NPC1 | |
| SCHEMBL13601724 | 0.79 | MAPT (0.44) | MAPTGAAALDH1A1NPC1L3MBTL1 | |
| SCHEMBL15139529 | 0.77 | POLB (0.45) | MAPTGAAHPGDALDH1A1NPC1 | |
| SCHEMBL28795016 | 0.76 | LMNA (0.45) | MAPTGAAHPGDALDH1A1NPC1 | |
| SCHEMBL13601702 | 0.76 | MAPT (0.49) | MAPTGAAHPGDALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |