Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12881476 | 0.84 | MAPT (0.46) | MAPTGAAALDH1A1L3MBTL1KDM4E | |
| SCHEMBL13601675 | 0.82 | MAPT (0.70) | MAPTGAAALDH1A1NPC1L3MBTL1 | |
| SCHEMBL13601735 | 0.81 | MAPT (0.41) | MAPTGAAALDH1A1L3MBTL1KDM4E | |
| SCHEMBL12881487 | 0.80 | ACHE (0.45) | MAPTGAAALDH1A1L3MBTL1KDM4E | |
| SCHEMBL13601693 | 0.79 | MAPT (0.46) | MAPTGAAALDH1A1NPC1L3MBTL1 | |
| SCHEMBL12881496 | 0.77 | L3MBTL1 (0.41) | MAPTGAAALDH1A1L3MBTL1KDM4E | |
| SCHEMBL13601690 | 0.77 | MAPT (0.44) | MAPTGAAALDH1A1NPC1L3MBTL1 | |
| SCHEMBL13601676 | 0.76 | MAPT (0.53) | MAPTGAAALDH1A1NPC1L3MBTL1 | |
| SCHEMBL13601361 | 0.75 | MAPT (0.38) | MAPTALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL13601680 | 0.73 | HPGD (0.56) | MAPTGAAALDH1A1NPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |