Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 11/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | PTGIS | Q16647 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1768417 | 0.75 | CYP11B1 (0.41) | CYP11B1CYP11B2TBXAS1PTGS1PTGS2 | |
| SCHEMBL3468050 | 0.71 | TBXAS1 (0.41) | CYP11B1CYP11B2TBXAS1PTGS1PTGS2 | |
| SCHEMBL15874826 | 0.66 | TBXAS1 (0.46) | TBXAS1PTGS1PTGS2PTGIS | |
| SCHEMBL9092547 | 0.65 | CYP11B1 (0.73) | CYP11B1CYP11B2TBXAS1GAA | |
| SCHEMBL31369919 | 0.62 | NAMPT (0.41) | CYP11B1CYP11B2TBXAS1PTGS1PTGS2 | |
| SCHEMBL31369367 | 0.61 | AGTR1 (0.38) | KDM4EMEN1KMT2A | |
| SCHEMBL28848248 | 0.61 | EGLN3 (0.43) | CYP11B1CYP11B2TBXAS1HDAC6KDM4E | |
| SCHEMBL19223362 | 0.61 | CYP11B1 (0.38) | CYP11B1CYP11B2TBXAS1ALDH1A1 | |
| SCHEMBL25244270 | 0.61 | KDM4E (0.46) | CYP11B1CYP11B2TBXAS1PTGS1PTGS2 | |
| SCHEMBL25283698 | 0.61 | KDM4E (0.46) | CYP11B1CYP11B2TBXAS1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618380-B1 | N epsilon AND/OR N alpha DERIVATIZED, METAL AND ORGANIC PROTECTED L-HISTIDINE FOR COUPLING TO BIOMOLECULES FOR HIGHLY EFFICIENT LABELING WITH (M(OH2)3(CO)3)+ BY FAC COORDINATION | UNIV ZUERICH (CH) | 2009-12-30 | — | — | EP | disclosed |