Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 10/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PTGIS | Q16647 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1768417 | 0.78 | CYP11B1 (0.41) | TBXAS1PTGS1PTGS2PTGISCYP11B1 | |
| SCHEMBL13601988 | 0.71 | CYP11B1 (0.40) | TBXAS1PTGS1PTGS2PTGISCYP11B1 | |
| SCHEMBL9092547 | 0.70 | CYP11B1 (0.73) | TBXAS1CYP11B1CYP11B2GAAKEAP1 | |
| SCHEMBL25244270 | 0.66 | KDM4E (0.46) | TBXAS1PTGS1PTGS2PTGISCYP11B1 | |
| SCHEMBL25283698 | 0.66 | KDM4E (0.46) | TBXAS1PTGS1PTGS2PTGISCYP11B1 | |
| SCHEMBL874048 | 0.62 | CHRM5 (0.41) | KDM4EALDH1A1 | |
| SCHEMBL2517712 | 0.62 | FFAR1 (0.49) | TBXAS1KEAP1P4HTM | |
| SCHEMBL27984196 | 0.62 | GABRA5 (0.37) | TBXAS1PTGS1PTGS2PTGISCYP11B1 | |
| SCHEMBL7011872 | 0.61 | KEAP1 (0.52) | TBXAS1KEAP1P4HTM | |
| SCHEMBL9645804 | 0.61 | ALDH1A1 (0.51) | KDM4EALDH1A1HSD17B10GAACNKSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021259227-A1 | ANTI-CD38 ANTIBODY AND USE THEREOF | 江苏康缘药业股份有限公司 | 2021-12-30 | — | — | WO | disclosed |
| US-10752678-B2 | Complement component C5 antibodies | ALLERGAN, INC. (US) | 2020-08-25 | — | — | US | disclosed |
| CN-105555803-A | Oncostatin m receptor antigen binding proteins | BIOGEN IDEC INC | 2016-05-04 | — | — | CN | disclosed |
| CN-105531285-A | Variants, compositions and methods of tissue inhibitors of type three metalloprotease (TIMP-3) | AMGEN INC | 2016-04-27 | — | — | CN | disclosed |
| CN-105418762-A | FC VARIANTS WITH ALTERED BINDING TO FCRN | XENCOR INC | 2016-03-23 | — | — | CN | disclosed |
| CN-103555735-B | Plant CO 2sensor, encode their nucleic acid and manufacture and their method of use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-03-09 | — | — | CN | disclosed |
| CN-105377889-A | Heterodimeric proteins | XENCOR INC | 2016-03-02 | — | — | CN | disclosed |
| CN-101558154-B | Phospholipases, nucleic acids encoding them, and methods of making and using them | DSM IP ASSETS B.V. (NL) | 2016-02-24 | — | — | CN | disclosed |
| CN-105358570-A | Aglycosylated Fc-containing polypeptides | AMGEN INC | 2016-02-24 | — | — | CN | disclosed |
| CN-105263948-A | Inhibition of pulmonary fibrosis with Nutlin-3a and peptides | UNIV TEXAS | 2016-01-20 | — | — | CN | disclosed |
| CN-101189264-A | M-CSF specific monoclonal antibody and application thereof | CHIRON CORP (US) | 2008-05-28 | — | — | CN | disclosed |
| CN-101171263-A | Method for humanizing immunoglobulin variable regions by rational modification of complementarity determining region residues | BIOGEN IDEC INC (US) | 2008-04-30 | — | — | CN | disclosed |
| CN-1871259-A | Improved antibodies having altered effector function and methods for making the same | BIOGEN IDEC INC (US) | 2006-11-29 | — | — | CN | disclosed |
| CN-1829741-A | Treatment with anti-VEGF antibodies | GENENTECH INC (US) | 2006-09-06 | — | — | CN | disclosed |
| CN-1260357-C | Improved anti-IgE antibodies and method of improving polypeptides | GENENTECH INC (US) | 2006-06-21 | — | — | CN | disclosed |
| EP-1511764-A2 | PEPTIDES AND PEPTIDOMIMETICS USEFUL FOR INHIBITING THE ACTIVITY OF PROSTAGLANDIN F sb 2a /sb RECEPTOR | THERATECHNOLOGIES INC. (CA) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003104266-A2 | PEPTIDES AND PEPTIDOMIMETICS USEFUL FOR INHIBITING THE ACTIVITY OF PROSTAGLANDIN F2α RECEPTOR | THERATECHNOLOGIES INC. (CA) | 2003-12-18 | — | — | WO | disclosed |
| CN-1268176-A | Improved anti-IgE antibodies and method of improving polypeptides | GENENTECH INC (US) | 2000-09-27 | — | — | CN | disclosed |
| WO-1998046744-A1 | INTRACELLULAR INTERACTORS AND EH DOMAIN BINDING SPECIFICITY | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 1998-10-22 | — | — | WO | disclosed |
| US-4631270-A | THIOMETHYLENE REPLACEMENTS | RESEARCH CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |