Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13603754 | 0.88 | NAMPT (0.80) | NAMPTSMN1; SMN2L3MBTL1LMNANPC1 | |
| SCHEMBL13603751 | 0.88 | NAMPT (0.65) | NAMPTSMN1; SMN2L3MBTL1LMNAROCK2 | |
| SCHEMBL28111895 | 0.84 | NAMPT (1.00) | NAMPTSMN1; SMN2L3MBTL1LMNACYP2C9 | |
| SCHEMBL11614852 | 0.82 | SMN1; SMN2 (0.81) | NAMPTSMN1; SMN2L3MBTL1LMNANPC1 | |
| Ammonia Solution, Strong SCHEMBL29131270 | 0.81 | SMN1; SMN2 (0.79) | NAMPTSMN1; SMN2L3MBTL1LMNANPC1 | |
| SCHEMBL103497 | 0.81 | NAMPT (0.63) | NAMPTSMN1; SMN2L3MBTL1LMNANPC1 | |
| SCHEMBL166124 | 0.81 | NAMPT (0.78) | NAMPT | |
| SCHEMBL14471485 | 0.80 | L3MBTL1 (0.72) | NAMPTSMN1; SMN2L3MBTL1LMNANPC1 | |
| Sulfur Dioxide SCHEMBL28161711 | 0.79 | SMN1; SMN2 (0.75) | NAMPTSMN1; SMN2L3MBTL1LMNANPC1 | |
| SCHEMBL2704691 | 0.78 | MAPT (0.66) | NAMPTSMN1; SMN2L3MBTL1NPC1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158076-A1 | Methylene Urea Derivatives | MERCK PATENT GMBH (DE) | 2013-06-20 | — | — | US | disclosed |
| US-8410143-B2 | Methylene urea derivatives | MERCK PATENT GMBH (DE) | 2013-04-02 | — | — | US | disclosed |
| US-20090298885-A1 | METHYLENE UREA DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298885-A1 | METHYLENE UREA DERIVATIVES | BRAF, RAF1, CMPK1 | NAMPT 1163/4885SMN1; SMN2 2976/4885L3MBTL1 3485/4885 |
| US-20130158076-A1 | Methylene Urea Derivatives | BRAF, RAF1, CMPK1 | NAMPT 1163/4885SMN1; SMN2 2976/4885L3MBTL1 3485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.