Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydromorphone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 10/20 | 0.79 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.79 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.79 |
| ▸ | MRGPRX2 | Q96LB1 | 3/20 | 0.75 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.75 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL250022 | 0.94 | OPRM1 (0.72) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Codeine SCHEMBL3239478 | 0.94 | OPRM1 (0.72) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Ethylmorphine SCHEMBL6471137 | 0.92 | OPRM1 (0.67) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Hydromorphone SCHEMBL16035915 | 0.92 | OPRM1 (0.71) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Hydrocodone SCHEMBL1359279 | 0.90 | OPRM1 (0.78) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Hydromorphone SCHEMBL19107004 | 0.89 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2LMNA | |
| Hydromorphone SCHEMBL12368741 | 0.89 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2LMNA | |
| Hydromorphone SCHEMBL10031237 | 0.89 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2LMNA | |
| Hydromorphone SCHEMBL16024201 | 0.89 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2LMNA | |
| Hydromorphone SCHEMBL6798556 | 0.89 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190330328-A1 | METHODS OF TREATING NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS USING INTERLEUKIN-17 (IL-17) ANTAGONISTS | NOVARTIS PHARMA GMBH (DE) | 2019-10-31 | — | — | US | disclosed |
| CN-110114457-A | Generate the method for removing first opiates and NAL- opiates benzyl isoquinoline alkaloid | 安思雅公司 | 2019-08-09 | — | — | CN | disclosed |
| EP-3365011-A1 | METHODS OF TREATING NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS USING INTERLEUKIN-17 (IL-17) ANTAGONISTS | Novartis AG (CH) | 2018-08-29 | — | — | EP | disclosed |
| CN-107960102-A | The method for producing epimerase and benzyl isoquinoline alkaloid | 小利兰·斯坦福大学托管委员会 | 2018-04-24 | — | — | CN | disclosed |
| WO-2017068472-A1 | METHODS OF TREATING NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS USING INTERLEUKIN-17 (IL-17) ANTAGONISTS | NOVARTIS AG (CH) | 2017-04-27 | — | — | WO | disclosed |
| US-8067243-B2 | Methods and systems for analyzing medication levels in a sample | OREGON MEDICAL LABORATORIES (US) | 2011-11-29 | — | — | US | disclosed |
| US-20100051801-A1 | METHODS AND SYSTEMS FOR ANALYZING MEDICATION LEVELS IN A SAMPLE | OREGON MEDICAL LABORATORIES | 2010-03-04 | — | — | US | disclosed |
| EP-1399161-A2 | SUSTAINED-RELEASE ANALGESIC COMPOUNDS | Control Delivery Systems (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2002098427-A2 | SUSTAINED-RELEASE ANALGESIC COMPOUNDS | CONTROL DELIVERY SYSTEMS (US) | 2002-12-12 | — | — | WO | disclosed |
| EP-0770387-B1 | Pharmaceutical composition containing a local anesthetic and/or centrally acting analgesic | BRAUN MELSUNGEN AG (DE) | 1999-08-11 | — | — | EP | disclosed |
| EP-0770387-A1 | Pharmaceutical composition containing a local anesthetic and/or centrally acting analgesic | B. BRAUN MELSUNGEN AG (DE) | 1997-05-02 | — | — | EP | disclosed |