Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ethylmorphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 11/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.67 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.67 |
| ▸ | MRGPRX2 | Q96LB1 | 5/20 | 0.64 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL250022 | 0.92 | OPRM1 (0.72) | OPRM1OPRK1OPRD1MRGPRX2SLC22A1 | |
| Codeine SCHEMBL3239478 | 0.92 | OPRM1 (0.72) | OPRM1OPRK1OPRD1MRGPRX2SLC22A1 | |
| Hydromorphone SCHEMBL1360640 | 0.92 | OPRD1 (0.79) | OPRM1OPRK1OPRD1MRGPRX2SLC22A1 | |
| Hydrocodone SCHEMBL1359279 | 0.88 | OPRM1 (0.78) | OPRM1OPRK1OPRD1MRGPRX2SLC22A1 | |
| Ethylmorphine SCHEMBL16922138 | 0.85 | OPRD1 (0.80) | OPRM1OPRK1OPRD1MRGPRX2SLC22A1 | |
| Ethylmorphine SCHEMBL14516212 | 0.85 | OPRD1 (0.80) | OPRM1OPRK1OPRD1MRGPRX2SLC22A1 | |
| Ethylmorphine SCHEMBL15757784 | 0.85 | OPRD1 (0.80) | OPRM1OPRK1OPRD1MRGPRX2SLC22A1 | |
| Ethylmorphine SCHEMBL14611951 | 0.85 | OPRD1 (0.80) | OPRM1OPRK1OPRD1MRGPRX2SLC22A1 | |
| Ethylmorphine SCHEMBL24971 | 0.85 | OPRD1 (0.80) | OPRM1OPRK1OPRD1MRGPRX2SLC22A1 | |
| Ethylmorphine SCHEMBL15653227 | 0.85 | OPRD1 (0.80) | OPRM1OPRK1OPRD1MRGPRX2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009377-A2 | NOVEL ORAL BIOAVAILABLE PRODRUGS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2005-02-03 | — | — | WO | disclosed |