Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocodone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 10/20 | 0.78 |
| ▸ | OPRD1 known ✓ | P41143 | 9/20 | 0.78 |
| ▸ | OPRK1 known ✓ | P41145 | 8/20 | 0.78 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.78 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.77 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.77 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.61 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL250022 | 0.96 | OPRM1 (0.72) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Codeine SCHEMBL3239478 | 0.96 | OPRM1 (0.72) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Oxycodone SCHEMBL7570264 | 0.91 | OPRM1 (0.65) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Hydromorphone SCHEMBL1360640 | 0.90 | OPRD1 (0.79) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Ethylmorphine SCHEMBL6471137 | 0.88 | OPRM1 (0.67) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Hydrocodone SCHEMBL277572 | 0.88 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Hydrocodone SCHEMBL12638883 | 0.88 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Hydrocodone SCHEMBL12402839 | 0.88 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Hydrocodone SCHEMBL21335350 | 0.88 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Hydrocodone SCHEMBL2987 | 0.88 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996213-A2 | METHOD AND COMPOSITIONS FOR POTENTIATING PHARMACEUTICALS WITH AMINO ACID BASED MEDICAL FOODS | Shell, William E. (US) | 2008-12-03 | — | — | EP | claimed |
| WO-2007111958-A2 | METHOD AND COMPOSITIONS FOR POTENTIATING PHARMACEUTICALS WITH AMINO ACID BASED MEDICAL FOODS | SHELL WILLIAM E (US) | 2007-10-04 | — | — | WO | claimed |
| US-20060159726-A1 | for producing acetylcholine and serotonin; improved cognitive function, induced and maintained sleep, reduced pain, inflammation, blood pressure, anxiety, asthma, duration of viral infection, insulin resistance, appetite, and treating depression | TARGETED MEDICAL PHARMA, INC. | 2006-07-20 | — | — | US | claimed |
| WO-2013019825-A1 | STEPWISE PROCESS FOR THE PRODUCTION OF ALKALOID SALTS | MALLINCKRODT LLC (US) | 2013-02-07 | — | — | WO | disclosed |
| US-8067243-B2 | Methods and systems for analyzing medication levels in a sample | OREGON MEDICAL LABORATORIES (US) | 2011-11-29 | — | — | US | disclosed |
| US-20100051801-A1 | METHODS AND SYSTEMS FOR ANALYZING MEDICATION LEVELS IN A SAMPLE | OREGON MEDICAL LABORATORIES | 2010-03-04 | — | — | US | disclosed |
| EP-1871774-A1 | METHOD FOR THE CATALYTIC PRODUCTION OF HYDROCODONE, HYDROMORPHONE, AND DERIVATIVES THEREOF | MALLINCKRODT, INC. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006104656-A1 | METHOD FOR THE CATALYTIC PRODUCTION OF HYDROCODONE, HYDROMORPHONE, AND DERIVATIVES THEREOF | MALLINCKRODT INC. (US) | 2006-10-05 | — | — | WO | disclosed |