Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053745 | 0.81 | ALDH1A1 (0.51) | ALDH1A1HSD17B10MEN1NPC1LMNA | |
| SCHEMBL13608086 | 0.79 | PTPN7 (0.44) | ALDH1A1HSD17B10MEN1NPC1LMNA | |
| SCHEMBL13607799 | 0.78 | CDK5 (0.48) | ALDH1A1NPC1LMNARAB9AKMT2A | |
| SCHEMBL13607804 | 0.78 | LMNA (0.42) | MEN1NPC1LMNARAB9AKMT2A | |
| SCHEMBL13607793 | 0.78 | RNASEH1 (0.43) | ALDH1A1HSD17B10LMNAKMT2AMAPK1 | |
| SCHEMBL13607784 | 0.77 | MAPT (0.40) | MEN1NPC1LMNARAB9AKMT2A | |
| SCHEMBL13607786 | 0.77 | HPGD (0.44) | ALDH1A1MEN1NPC1LMNARAB9A | |
| SCHEMBL13607995 | 0.77 | HPGD (0.45) | ALDH1A1HSD17B10MEN1NPC1LMNA | |
| SCHEMBL13607779 | 0.77 | GAA (0.50) | ALDH1A1NPC1LMNARAB9AKMT2A | |
| SCHEMBL13607764 | 0.77 | PARP1 (0.51) | ALDH1A1HSD17B10MEN1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |