Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13607972 | 0.88 | RAB9A (0.51) | PDE10ARAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL13608670 | 0.87 | PDE10A (0.44) | PDE10ARAB9ANPC1GRIN1GRIN2B | |
| SCHEMBL13608709 | 0.84 | RAB9A (0.52) | PDE10ARAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL13608641 | 0.84 | TUBB4A (0.49) | PDE10ANTRK1NTRK2RAB9ANPC1 | |
| SCHEMBL13608653 | 0.84 | NTRK1 (0.46) | PDE10ANTRK1NTRK2RAB9ANPC1 | |
| SCHEMBL13608668 | 0.84 | TRPV1 (0.42) | TRPV1PDE10AFGFR2FGFR3NTRK1 | |
| SCHEMBL13607871 | 0.82 | FGFR2 (0.43) | TRPV1PDE10AFGFR2FGFR3NTRK1 | |
| SCHEMBL4059226 | 0.81 | NOS3 (0.53) | TRPV1PDE10ANTRK1NTRK2RAB9A | |
| SCHEMBL13608671 | 0.81 | RIPK1 (0.44) | PDE10AFGFR3RAB9ANPC1GRIN1 | |
| SCHEMBL13608679 | 0.81 | PDE10A (0.42) | PDE10ANTRK1RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |