Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 8/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | STK4 | Q13043 | 1/20 | 0.40 |
| ▸ | STK3 | Q13188 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1752990 | 0.83 | KMT2A (0.51) | ACHETDP1 | |
| SCHEMBL1752927 | 0.80 | HRH4 (0.51) | ACHECYP1A2CYP2D6CNR1 | |
| SCHEMBL1752949 | 0.80 | NPY5R (0.49) | ACHECYP3A4CYP1A2CYP2D6 | |
| SCHEMBL1753200 | 0.80 | MAPT (0.47) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL1752980 | 0.79 | LMNA (0.55) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| Minozac Free Base SCHEMBL1752767 | 0.77 | MAPT (0.48) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| Minozac Free Base SCHEMBL2799232 | 0.76 | TSHR (0.47) | LMNACYP3A4 | |
| SCHEMBL13611647 | 0.76 | KHK (0.43) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| Minozac Free Base SCHEMBL29369390 | 0.76 | TSHR (0.47) | LMNACYP3A4 | |
| SCHEMBL1753067 | 0.75 | ACHE (0.39) | ACHELMNACYP3A4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325973-A1 | FORMULATIONS CONTAINING PYRIDAZINE COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325973-A1 | FORMULATIONS CONTAINING PYRIDAZINE COMPOUNDS | TST, SRMS, STS | PTPN11 610/4885ACHE 3027/4885STK4 871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.