Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14236109 | 0.90 | ALDH1A1 (0.39) | SMYD3ALDH1A1KDM4EGAAHSD17B10 | |
| SCHEMBL3836019 | 0.86 | SMYD3 (0.49) | SMYD3ALDH1A1KDM4EGAAHSD17B10 | |
| SCHEMBL3830963 | 0.84 | RAB9A (0.49) | L3MBTL1SMYD3ALDH1A1KDM4EGAA | |
| SCHEMBL3834363 | 0.80 | KDR (0.44) | SMYD3ALDH1A1KDM4EGAAHSD17B10 | |
| SCHEMBL3829482 | 0.79 | CNR2 (0.48) | L3MBTL1 | |
| SCHEMBL3197147 | 0.77 | PARP1 (0.44) | ALDH1A1KDM4EGAAHSD17B10 | |
| SCHEMBL14235995 | 0.75 | RAB9A (0.49) | SMYD3ALDH1A1KDM4EGAAHSD17B10 | |
| SCHEMBL13613365 | 0.75 | TERT (0.44) | ALDH1A1KDM4EGAAHSD17B10RAB9A | |
| SCHEMBL3829261 | 0.74 | KDM4E (0.54) | L3MBTL1ALDH1A1KDM4EGAAHSD17B10 | |
| SCHEMBL3205729 | 0.74 | KIF11 (0.43) | ALDH1A1KDM4EGAARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119703-A1 | NOVEL INDOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON I B KINASE | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-18 | — | — | EP | disclosed |