Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714028 | 0.88 | FFAR1 (0.55) | FFAR1FFAR4L3MBTL1LMNALTB4R | |
| SCHEMBL7619725 | 0.85 | FFAR1 (0.52) | FFAR1FFAR4L3MBTL1LMNALTB4R | |
| SCHEMBL8505531 | 0.85 | FFAR1 (0.52) | FFAR1FFAR4L3MBTL1LMNALTB4R | |
| SCHEMBL7712069 | 0.84 | FFAR1 (0.53) | FFAR1FFAR4L3MBTL1LMNALTB4R | |
| SCHEMBL13628909 | 0.84 | S1PR1 (0.59) | L3MBTL1LMNAKDM4E | |
| Potassium Ion SCHEMBL7619825 | 0.82 | L3MBTL1 (0.49) | FFAR1FFAR4L3MBTL1LMNALTB4R | |
| SCHEMBL7617244 | 0.81 | NPC1 (0.50) | FFAR1FFAR4L3MBTL1LMNALTB4R | |
| SCHEMBL6713395 | 0.80 | ALOX5 (0.52) | FFAR1FFAR4L3MBTL1LMNALTB4R | |
| SCHEMBL1497875 | 0.80 | ALDH1A1 (0.60) | FFAR1FFAR4L3MBTL1LMNALTB4R | |
| SCHEMBL3108951 | 0.80 | ALDH1A1 (0.47) | FFAR1FFAR4L3MBTL1LMNALTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612238-B2 | Such as (R)-2-amino-2-methyl-4-[4-(4,4,5,5,5-pentafluoro-pentyloxy)-phenyl]-butan-1-ol hydrochloride for treatment of disorders or diseases mediated by lymphocytes, and for treating acute or chronic transplant rejection or T-cell-mediated inflammatory or autoimmune diseases | NOVARTIS AG (CH) | 2009-11-03 | — | — | US | disclosed |