Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5991929 | 0.89 | ALDH1A1 (0.74) | ALDH1A1RECQLATMTHRBTAAR1 | |
| SCHEMBL3108951 | 0.88 | ALDH1A1 (0.47) | ALDH1A1RECQLLMNAL3MBTL1FFAR1 | |
| SCHEMBL14555216 | 0.87 | ALDH1A1 (0.61) | ALDH1A1RECQLATMTHRBTAAR1 | |
| SCHEMBL8538518 | 0.86 | ALDH1A1 (0.66) | ALDH1A1RECQLATMTHRBTAAR1 | |
| SCHEMBL6506349 | 0.84 | ALDH1A1 (0.64) | ALDH1A1RECQLATMTHRBTAAR1 | |
| SCHEMBL7714028 | 0.82 | FFAR1 (0.55) | ALDH1A1LMNAL3MBTL1FFAR1FFAR4 | |
| SCHEMBL1563297 | 0.82 | ALDH1A1 (0.46) | ALDH1A1RECQLATMLMNAL3MBTL1 | |
| SCHEMBL8500276 | 0.82 | ATM (0.61) | ALDH1A1RECQLATMTHRBL3MBTL1 | |
| SCHEMBL8497043 | 0.82 | ATM (0.61) | ALDH1A1RECQLATMTHRBL3MBTL1 | |
| SCHEMBL8538236 | 0.82 | ATM (0.61) | ALDH1A1RECQLATMTHRBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120277194-A1 | AMINOPROPANOL DERIVATIVES | ALBERT RAINER (CH) | 2012-11-01 | — | — | US | disclosed |
| US-20110118210-A1 | AMINOPROPANOL DERIVATIVES | ALBERT RAINER | 2011-05-19 | — | — | US | disclosed |
| US-7902175-B2 | Aminopropanol derivatives | NOVARTIS AG (CH) | 2011-03-08 | — | — | US | disclosed |
| EP-1660449-B1 | AMINOPROPANOL DERIVATIVES | NOVARTIS AG (CH) | 2009-11-18 | — | — | EP | disclosed |
| US-7612238-B2 | Such as (R)-2-amino-2-methyl-4-[4-(4,4,5,5,5-pentafluoro-pentyloxy)-phenyl]-butan-1-ol hydrochloride for treatment of disorders or diseases mediated by lymphocytes, and for treating acute or chronic transplant rejection or T-cell-mediated inflammatory or autoimmune diseases | NOVARTIS AG (CH) | 2009-11-03 | — | — | US | disclosed |
| US-7612238-B2 | Such as (R)-2-amino-2-methyl-4-[4-(4,4,5,5,5-pentafluoro-pentyloxy)-phenyl]-butan-1-ol hydrochloride for treatment of disorders or diseases mediated by lymphocytes, and for treating acute or chronic transplant rejection or T-cell-mediated inflammatory or autoimmune diseases | NOVARTIS AG (CH) | 2009-11-03 | — | — | US | disclosed |
| US-20090156556-A1 | AMINOPROPANOL DERIVATIVES | ALBERT RAINER | 2009-06-18 | — | — | US | disclosed |
| US-7528120-B2 | Aminopropanol derivatives | NOVARTIS AG (CH) | 2009-05-05 | — | — | US | disclosed |
| US-20060264403-A1 | Aminopropanol derivatives | NOVARTIS AG (CH) | 2006-11-23 | — | — | US | disclosed |
| US-20060166940-A1 | Amino-propanol derivatives | NOVARTIS AG (CH) | 2006-07-27 | — | — | US | disclosed |
| EP-1660449-A1 | AMINOPROPANOL DERIVATIVES | Novartis AG (CH) | 2006-05-31 | — | — | EP | disclosed |
| EP-1539674-A1 | AMINO-PROPANOL DERIVATIVES | Novartis AG (CH) | 2005-06-15 | — | — | EP | disclosed |
| WO-2005021503-A1 | AMINOPROPANOL DERIVATIVES | NOVARTIS AG (CH) | 2005-03-10 | — | — | WO | disclosed |
| WO-2004024673-A1 | AMINO-PROPANOL DERIVATIVES | NOVARTIS AG (CH) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118210-A1 | AMINOPROPANOL DERIVATIVES | ADRB1, ADRA1D, ADRA1A | ALDH1A1 94/4885RECQL 4066/4885ATM 487/4885 |
| US-20090156556-A1 | AMINOPROPANOL DERIVATIVES | ADRB1, ADRA1D, ADRA1A | ALDH1A1 94/4885RECQL 4066/4885ATM 487/4885 |
| US-20060166940-A1 | Amino-propanol derivatives | ADRB1, ADRB3, ADRA1D | ALDH1A1 311/4885RECQL 4118/4885ATM 1378/4885 |
| US-20120277194-A1 | AMINOPROPANOL DERIVATIVES | ADRB1, ADRA1D, ADRA1A | ALDH1A1 94/4885RECQL 4066/4885ATM 487/4885 |
| US-20060264403-A1 | Aminopropanol derivatives | ADRB1, ADRA1D, ADRA1A | ALDH1A1 94/4885RECQL 4066/4885ATM 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.