Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.56 |
| ▸ | CA9 | Q16790 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3528445 | 0.89 | CA12 (0.58) | CA12CA9CISD1ATMALDH1A1 | |
| SCHEMBL3528864 | 0.85 | CA12 (0.55) | CA12CA9CISD1ATMALDH1A1 | |
| SCHEMBL13544519 | 0.80 | CA12 (0.55) | CA12CA9CISD1ATMALDH1A1 | |
| SCHEMBL13684737 | 0.79 | CA12 (0.47) | CA12CA9MAPTTP53LMNA | |
| SCHEMBL13542944 | 0.78 | CA12 (0.49) | CA12CA9MAPTALDH1A1L3MBTL1 | |
| SCHEMBL2540297 | 0.77 | CA12 (0.47) | CA12CA9LMNAATMALDH1A1 | |
| SCHEMBL13614188 | 0.76 | L3MBTL1 (0.38) | CA12CA9MAPTTP53LMNA | |
| SCHEMBL7764035 | 0.76 | SLC9A1 (0.45) | LMNAALDH1A1 | |
| SCHEMBL21623170 | 0.74 | CA12 (0.38) | CA12CA9LMNACISD1ATM | |
| SCHEMBL13543496 | 0.73 | CA12 (0.54) | CA12CA9MAPTTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432700-B1 | SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-04 | — | — | EP | disclosed |