Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ESRRB | O95718 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2305014 | 0.83 | HSD17B3 (0.60) | KMT2AMAPTLMNAALDH1A1HTT | |
| SCHEMBL8535748 | 0.83 | KMT2A (0.63) | KMT2AMAPTLMNAALDH1A1HTT | |
| SCHEMBL640759 | 0.81 | LMNA (0.60) | KMT2AMAPTLMNAALDH1A1HTT | |
| SCHEMBL7398 | 0.81 | KMT2A (0.64) | KMT2AMAPTLMNAALDH1A1HTT | |
| SCHEMBL10787656 | 0.81 | KMT2A (0.48) | KMT2AMAPTLMNAALDH1A1HTT | |
| SCHEMBL10638823 | 0.81 | KMT2A (0.48) | KMT2AMAPTLMNAALDH1A1HTT | |
| SCHEMBL9263357 | 0.81 | KMT2A (0.60) | KMT2AMAPTLMNAALDH1A1HTT | |
| SCHEMBL1108994 | 0.81 | MMP1 (0.70) | KMT2AMAPTLMNAALDH1A1HTT | |
| SCHEMBL135356 | 0.81 | NR4A2 (0.61) | KMT2AMAPTLMNAALDH1A1HTT | |
| SCHEMBL3457642 | 0.80 | KMT2A (0.47) | KMT2AMAPTLMNAALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432700-B1 | SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-04 | — | — | EP | disclosed |