Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.72 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.63 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.57 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.57 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.57 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.57 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.55 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | CCR9 | P51686 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13852837 | 0.85 | HSD17B2 (0.68) | FFAR4KEAP1NFE2L2ALDH1A1GAA | |
| SCHEMBL13852836 | 0.85 | KEAP1 (0.64) | FFAR4KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL13615288 | 0.83 | HSD17B2 (0.57) | FFAR4HSD17B2CYP2C9 | |
| SCHEMBL13852833 | 0.83 | HSD17B2 (0.63) | FFAR4ALDH1A1HSD17B2CCR9 | |
| SCHEMBL13615284 | 0.83 | ALDH1A1 (0.60) | MEN1KMT2AALDH1A1GAAHSD17B10 | |
| SCHEMBL5955289 | 0.83 | KEAP1 (0.53) | FFAR4KEAP1NFE2L2SQSTM1KMT2A | |
| SCHEMBL15248886 | 0.81 | HSD17B2 (0.74) | FFAR4MEN1KMT2AALDH1A1HSD17B2 | |
| SCHEMBL13629459 | 0.80 | FFAR4 (0.71) | FFAR4KEAP1NFE2L2SQSTM1GABRG2 | |
| SCHEMBL16187974 | 0.79 | HSD17B2 (0.67) | ALDH1A1GAACYTH2HSD17B2 | |
| SCHEMBL23555177 | 0.78 | KEAP1 (1.00) | FFAR4KEAP1NFE2L2SQSTM1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275593-A1 | 3 Substituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors | NOVARTIS AG | 2009-11-05 | — | — | US | disclosed |
| US-20090118277-A1 | 3 Unsubstituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors | NOVARTIS AG | 2009-05-07 | — | — | US | disclosed |
| US-20090118277-A1 | 3 Unsubstituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors | NOVARTIS AG | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118277-A1 | 3 Unsubstituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors | TIE1, TEK, MATK | FFAR4 3554/4885KEAP1 529/4885NFE2L2 1106/4885 |
| US-20090275593-A1 | 3 Substituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors | TIE1, TEK, MATK | FFAR4 3913/4885KEAP1 682/4885NFE2L2 1321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.