Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.53 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.53 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.53 |
| ▸ | CCR9 | P51686 | 2/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.51 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.49 |
| ▸ | BRD1 | O95696 | 1/20 | 0.49 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | UQCRB | P14927 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5956219 | 0.91 | KEAP1 (0.63) | KEAP1NFE2L2SQSTM1FFAR4PGR | |
| SCHEMBL5955223 | 0.85 | FFAR4 (0.68) | KEAP1NFE2L2SQSTM1FFAR4PGR | |
| SCHEMBL5955308 | 0.85 | PGR (0.70) | KEAP1NFE2L2SQSTM1FFAR4PGR | |
| SCHEMBL5955419 | 0.84 | LMNA (0.64) | KEAP1NFE2L2SQSTM1FFAR4PGR | |
| SCHEMBL5955381 | 0.84 | STAT3 (0.60) | KEAP1NFE2L2SQSTM1FFAR4PGR | |
| SCHEMBL5955460 | 0.84 | PGR (0.65) | KEAP1NFE2L2SQSTM1FFAR4PGR | |
| SCHEMBL13615106 | 0.83 | FFAR4 (0.72) | KEAP1NFE2L2SQSTM1FFAR4CCR9 | |
| SCHEMBL5955241 | 0.82 | KEAP1 (0.53) | KEAP1NFE2L2SQSTM1FFAR4PGR | |
| SCHEMBL5955279 | 0.82 | KEAP1 (0.53) | KEAP1NFE2L2SQSTM1FFAR4PGR | |
| SCHEMBL5956042 | 0.81 | FFAR4 (0.62) | KEAP1NFE2L2SQSTM1FFAR4PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006014405-A2 | SULFONAMIDE-BASED COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-02-09 | — | — | WO | claimed |
| US-20060004197-A1 | Sulfonamide-based compounds as protein tyrosine kinase inhibitors | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2006-01-05 | — | — | US | claimed |
| US-20060004197-A1 | Sulfonamide-based compounds as protein tyrosine kinase inhibitors | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004197-A1 | Sulfonamide-based compounds as protein tyrosine kinase inhibitors | SRC, LCK, ABL1 | KEAP1 1455/4885NFE2L2 2514/4885SQSTM1 2062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.