Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 7/20 | 0.71 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.62 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.59 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13852947 | 0.86 | NPC1 (0.58) | FFAR4KEAP1CYTH2ALDH1A1CYP2C9 | |
| SCHEMBL13852970 | 0.83 | ALDH1A1 (0.60) | FFAR4ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL13629390 | 0.82 | ALDH1A1 (0.57) | ALDH1A1NPSR1HTTKMT2AMEN1 | |
| SCHEMBL5955241 | 0.82 | KEAP1 (0.53) | FFAR4KEAP1ALDH1A1NPSR1TSHR | |
| SCHEMBL13629343 | 0.80 | NPC1 (0.52) | FFAR4CYP2C9HTTKMT2ALMNA | |
| SCHEMBL13615106 | 0.80 | FFAR4 (0.72) | FFAR4KEAP1GABRG2GABRB3GABRA3 | |
| SCHEMBL8752431 | 0.79 | UCHL1 (0.71) | KEAP1ALDH1A1NPSR1TSHRNFE2L2 | |
| SCHEMBL6928661 | 0.79 | UCHL1 (0.71) | KEAP1ALDH1A1NPSR1TSHRNFE2L2 | |
| SCHEMBL7320098 | 0.78 | FFAR4 (0.60) | FFAR4KEAP1GABRG2GABRB3GABRA3 | |
| SCHEMBL13629419 | 0.78 | NPC1 (0.49) | FFAR4ALDH1A1TP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275593-A1 | 3 Substituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors | NOVARTIS AG | 2009-11-05 | — | — | US | disclosed |
| US-20090118277-A1 | 3 Unsubstituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors | NOVARTIS AG | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118277-A1 | 3 Unsubstituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors | TIE1, TEK, MATK | FFAR4 3554/4885KEAP1 529/4885GABRG2 3450/4885 |
| US-20090275593-A1 | 3 Substituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors | TIE1, TEK, MATK | FFAR4 3913/4885KEAP1 682/4885GABRG2 3478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.