Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.38 |
| ▸ | FURIN | P09958 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8242887 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL3456181 | 0.76 | ALDH1A1 (0.44) | KMT2AALDH1A1CYP3A4CA9HSD11B1 | |
| SCHEMBL3456178 | 0.76 | ALDH1A1 (0.44) | KMT2AALDH1A1CYP3A4CA9HSD11B1 | |
| SCHEMBL11318302 | 0.75 | NPSR1 (0.56) | SMN1; SMN2MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL8661356 | 0.75 | KMT2A (0.47) | SMN1; SMN2MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL7622154 | 0.75 | KMT2A (0.47) | SMN1; SMN2MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL3228942 | 0.74 | NPFFR2 (0.61) | SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL7537876 | 0.74 | NPFFR2 (0.61) | SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL2866567 | 0.73 | HSD11B1 (0.48) | ALDH1A1CYP3A4CA9HSD11B1 | |
| SCHEMBL14415900 | 0.73 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CA9NPFFR2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612069-B2 | Acyl guanidines as beta-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-03 | — | — | US | disclosed |
| US-7273882-B2 | Aminoacetamide acyl guanidines as β-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-09-25 | — | — | US | disclosed |
| US-20070015754-A1 | Acyl guanidines as beta-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015754-A1 | Acyl guanidines as beta-secretase inhibitors | BACE1, APP, BACE2 | SMN1; SMN2 630/4885MEN1 3522/4885KMT2A 3022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.