Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203578 | 0.76 | SMN1; SMN2 (0.35) | SMN1; SMN2ABL1BCRCRHR1 | |
| SCHEMBL1203941 | 0.76 | TTK (0.35) | SMN1; SMN2ABL1BCRCRHR1 | |
| SCHEMBL13616148 | 0.75 | MAPK1 (0.45) | — | |
| SCHEMBL4189963 | 0.73 | USP1 (0.39) | SMN1; SMN2ABL1BCR | |
| SCHEMBL12381902 | 0.70 | MTNR1A (0.44) | — | |
| SCHEMBL20251041 | 0.69 | PIK3R1 (0.33) | — | |
| SCHEMBL12384206 | 0.67 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL13616133 | 0.66 | SMN1; SMN2 (0.32) | SMN1; SMN2 | |
| SCHEMBL3538717 | 0.66 | SMN1; SMN2 (0.34) | SMN1; SMN2ABL1BCR | |
| SCHEMBL27810553 | 0.65 | GAA (0.47) | SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324225-B2 | Pyrrolopyrimidine compounds and their uses | NOVARTIS AG (CH) | 2012-12-04 | — | — | US | disclosed |
| US-20090318441-A1 | Pyrrolopyrimidine Compounds and Their Uses | ASTEX THERAPEUTICS LTD. | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318441-A1 | Pyrrolopyrimidine Compounds and Their Uses | PRKDC, TK2, PNKP | SMN1; SMN2 2559/4885ABL1 292/4885BCR 1482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.