Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GSR | P00390 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1827511 | 1.00 | LMNA (0.42) | LMNAKMT2AALDH1A1MAPTIGLV6-57 | |
| SCHEMBL6233892 | 0.89 | PTGS2 (0.41) | ALDH1A1MAPTFFAR1CYP2D6 | |
| Nitrobenzene SCHEMBL28169232 | 0.86 | ALDH1A1 (0.47) | LMNAKMT2AALDH1A1MAPTGSR | |
| SCHEMBL4669959 | 0.85 | AOC3 (0.39) | LMNAKMT2AALDH1A1MAPTPOLB | |
| SCHEMBL4670365 | 0.82 | ALDH1A1 (0.37) | LMNAKMT2AALDH1A1FFAR1MEN1 | |
| SCHEMBL9572581 | 0.82 | POLB (0.42) | ALDH1A1POLB | |
| SCHEMBL4911976 | 0.82 | LMNA (0.43) | LMNAIGLV6-57POLBGSRSLC6A4 | |
| SCHEMBL10071710 | 0.81 | AOC3 (0.41) | ALDH1A1MAPTSLC6A4CYP2D6 | |
| SCHEMBL9572555 | 0.80 | SLC7A5 (0.40) | LMNAALDH1A1POLB | |
| SCHEMBL27280983 | 0.80 | TAAR1 (0.46) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1477186-B1 | ANTIPRURITICS | SHIONOGI & CO (JP) | 2009-11-11 | — | — | EP | disclosed |