Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4911785 | 0.84 | AOC3 (0.40) | LMNASLC6A4HTR2AHRH1AOC3 | |
| SCHEMBL1827511 | 0.82 | LMNA (0.42) | LMNASLC6A4MIFIGLV6-57POLB | |
| SCHEMBL13616887 | 0.82 | LMNA (0.42) | LMNASLC6A4MIFIGLV6-57POLB | |
| SCHEMBL4920321 | 0.82 | LMNA (0.42) | LMNASLC6A4MIFSLC7A5IGLV6-57 | |
| SCHEMBL4922171 | 0.79 | LMNA (0.39) | LMNASLC6A4MIFSLC7A5IGLV6-57 | |
| SCHEMBL36373 | 0.78 | LMNA (0.50) | LMNASLC6A4MIFSLC7A5TRPA1 | |
| SCHEMBL2792023 | 0.78 | LMNA (0.50) | LMNASLC6A4MIFSLC7A5IGLV6-57 | |
| SCHEMBL11915432 | 0.76 | LMNA (0.48) | LMNASLC6A4MIFSLC7A5IGLV6-57 | |
| SCHEMBL8269660 | 0.76 | LMNA (0.48) | LMNASLC6A4MIFSLC7A5IGLV6-57 | |
| SCHEMBL1068693 | 0.76 | LMNA (0.48) | LMNASLC6A4MIFSLC7A5IGLV6-57 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200475-A1 | 4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors | PFIZER INC. | 2008-08-21 | — | — | US | disclosed |
| EP-1866317-A1 | 4-PIPERAZINOTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006103555-A1 | 4-PIPERAZINOTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-10-05 | — | — | WO | disclosed |
| US-7071211-B2 | Small organic molecules that increase the activity of gelatinase a in ocular cells | BAUSCH & LOMB INC. (US) | 2006-07-04 | — | — | US | disclosed |
| US-20060121090-A1 | Ocular compositions that increases the activity of gelatinase a in ocular cells | BAUSCH & LOMB INCORPORATED | 2006-06-08 | — | — | US | disclosed |
| EP-1542687-A1 | SMALL ORGANIC MOLECULES THAT INCREASE THE ACTIVITY OF GELATINASE A IN OCULAR CELLS | BAUSCH & LOMB INCORPORATED (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004028538-A1 | SMALL ORGANIC MOLECULES THAT INCREASE THE ACTIVITY OF GELATINASE A IN OCULAR CELLS | BAUSCH & LOMB INCORPORATED (US) | 2004-04-08 | — | — | WO | disclosed |
| US-20040068017-A1 | Small organic molecules that increase the activity of Gelatinase A in ocular cells | BAUSCH & LOMB INCORPORATED | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060121090-A1 | Ocular compositions that increases the activity of gelatinase a in ocular cells | MMP3, MMP13, MMP1 | LMNA 483/4885SLC6A4 4690/4885MIF 356/4885 |
| US-20040068017-A1 | Small organic molecules that increase the activity of Gelatinase A in ocular cells | MMP1, MMP3, MMP10 | LMNA 1181/4885SLC6A4 3927/4885MIF 185/4885 |
| US-20080200475-A1 | 4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors | PF4, TBXA2R, P2RY4 | LMNA 3156/4885SLC6A4 646/4885MIF 4189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.