Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.44 |
| ▸ | ARNT | P27540 | 4/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
| ▸ | XPO1 | O14980 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13616848 | 0.88 | MAP4K4 (0.38) | MAP4K4CYP1A2CYP3A4THPOLMNA | |
| SCHEMBL13398555 | 0.75 | KDM4E (0.54) | MAP4K4ARNTEPAS1XPO1CYP1A2 | |
| SCHEMBL13616809 | 0.75 | DHFR (0.47) | MAP4K4TDO2DPP4 | |
| SCHEMBL13616873 | 0.70 | CLK1 (0.37) | MAP4K4DPP4EPHB4CYP3A4LMNA | |
| SCHEMBL13398582 | 0.68 | XPO1 (0.45) | XPO1CYP1A2CYP3A4THPOLMNA | |
| SCHEMBL13616861 | 0.62 | PIM1 (0.40) | EPHB4 | |
| SCHEMBL1231814 | 0.62 | HSP90AA1 (0.36) | — | |
| SCHEMBL17667859 | 0.61 | ADORA2A (0.51) | — | |
| SCHEMBL13616945 | 0.61 | ADORA2A (0.48) | CYP1A2CYP3A4BRD4 | |
| SCHEMBL10432894 | 0.61 | KDM4E (0.35) | CYP1A2CYP3A4THPOLMNAPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119716-A1 | AZA-BRIDGED-RING COMPOUND | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |