Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 4/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.31 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13616949 | 0.88 | MAP4K4 (0.44) | MAP4K4CYP1A2CYP3A4THPOLMNA | |
| SCHEMBL10432894 | 0.71 | KDM4E (0.35) | CYP1A2CYP3A4THPOLMNAPMP22 | |
| SCHEMBL9586083 | 0.71 | KDM4E (0.62) | CYP1A2CYP3A4THPOLMNAPMP22 | |
| SCHEMBL13616945 | 0.67 | ADORA2A (0.48) | ADORA2AADORA1CYP1A2CYP3A4 | |
| SCHEMBL13616808 | 0.67 | ALDH1A1 (0.46) | MAP4K4ADORA2AADORA1MEN1KMT2A | |
| SCHEMBL12631776 | 0.67 | HSD17B1 (0.49) | MAP4K4ADORA1CYP3A4 | |
| SCHEMBL13616873 | 0.66 | CLK1 (0.37) | MAP4K4CYP3A4LMNAKDM4EMEN1 | |
| SCHEMBL13616805 | 0.65 | MPL (0.47) | MAP4K4ADORA2AADORA1KDM4E | |
| SCHEMBL9586019 | 0.65 | CYP1A2 (0.78) | ADORA2ACYP1A2CYP3A4THPOLMNA | |
| SCHEMBL1231814 | 0.64 | HSP90AA1 (0.36) | PI4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119716-A1 | AZA-BRIDGED-RING COMPOUND | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |